Jordan E. Bisanz

Dietary fiber-type-specific gut microbiome preconditioning drives differential susceptibility to sporadic colon cancer development

The paper shows that inulin supplementation increases colon tumor incidence in mice by altering gut microbiome and metabolome, creating a tumor-promoting environment when exposed to carcinogens.

Human Gut Bacteria Convert Endogenous Steroids into Host Cortisol Shuttle Inhibitors

The paper identifies gut bacteria-produced metabolites that inhibit HSD11B2, altering cortisol signaling and linking microbiome activity to blood pressure regulation.

Coordinated variation in the immune systems and microbiomes of healthy humans is linked to tonic interferon states

The paper identifies coordinated variation between immune systems and microbiomes in healthy humans, linking it to tonic interferon states.

Soilless system design impacts the diversity and composition of microbiota

This study examines how different soilless farming systems and seasonal conditions affect microbial communities in nutrient solutions and plant leaves.

StrainR2 accurately deconvolutes strain-level abundances in synthetic microbial communities

StrainR2 accurately deconvolutes strain-level abundances in synthetic microbial communities using shotgun metagenomic sequencing and k-mer normalization.

Set1/COMPASS repels heterochromatin invasion at euchromatic sites by disrupting Suv39/Clr4 activity and nucleosome stability

The paper identifies a mechanism by which Set1/COMPASS prevents heterochromatin invasion at euchromatic sites through inhibition of Suv39/Clr4 and disruption of nucleosome stability.