CPSF6 Promotes HIV-1 Preintegration Complex Function
Evan Chaudhuri, Sooin Jang, Rajasree Chakraborty, Rajalingam Radhakrishnan, Bjarki Arnarson, Prem Prakash, Daphne Cornish, Nicholas Rohlfes, Parmit Kumar Singh, Jiong Shi, Christopher Aiken, Edward M. Campbell, Judd F. Hultquist, Alan Engelman, Muthukumar Balsubramaniam, Chandravanu Dash
This study shows CPSF6 promotes HIV-1 preintegration complex function by enhancing viral DNA integration into gene-dense regions and restoring integration activity when added back to mutant cells.
Journal of Virology · Apr 9, 2025Peer-reviewedBiochemistry