Structural insights into inhibitor mechanisms on immature HIV-1 Gag lattice revealed by high-resolution in situ single-particle cryo-EM
Chunxiang Wu, Megan E. Meuser, Juan S. Rey, Hamed Meshkin, Rachel Yang, Swapnil C. Devarkar, Christian Freniere, Jiong Shi, Christopher Aiken, Juan R. Perilla, Yong Xiong
This study determines high-resolution structures of immature HIV-1 particles with inhibitors BVM and LEN bound using cryo-EM, revealing their distinct binding mechanisms and effects on Gag lattice architecture.
Journal of the American Chemical Society · Nov 6, 2025Peer-reviewedBiochemistry