Author

Bryan M. Spann

University of Southern California

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Research Focus:differential expression· 2 Assay:imaging· 2 Research Focus:benchmarking· 1 Assay:GWAS summary statistics· 1 Approach:machine learning (classical)· 1 Research Focus:polygenic risk· 1

Frequent Co-Authors

Adam FleisheriD· 4 shared Arthur W. TogaiD· 4 shared Beau M. AncesiD· 4 shared Betty Lind· 4 shared Clifford R. JackiD· 4 shared Helen Vanderswag· 4 shared Jeffrey Alan KayeiD· 4 shared John C. MorrisiD· 4 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Adam FleisherORCID

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Author profile →

5 papers

Recent·Most cited

Polygenic effects on the risk of Alzheimer's disease in the Japanese population

Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, the Alzheimer’s Disease Neuroimaging Initiative, , Gary R. Conrad

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

Alzheimer s Research & Therapy · Feb 27, 2024Peer-reviewedGenetic & Genomic Medicine

Spread of pathological tau proteins through communicating neurons in human Alzheimer’s disease

Jacob W. Vogel, Yasser Iturria‐Medina, Olof T. Strandberg, Ruben A Smith, Elizabeth Levitis, Alan Charles Evans, Oskar Hansson, Alzheimer’s Disease Neuroimaging Initiative, Michael Walter Weiner, Paul Aisen, Ronald Carl Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, , Mark A. Mintun

This study uses an epidemic spreading model to show that tau spreads through neuronal connections in Alzheimer's disease, with beta-amyloid accelerating this process in some brain regions.

Nature Communications · May 26, 2020Peer-reviewedNeuroscience

Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Kilian Hett, Vinh‐Thong Ta, Gwénaëlle Catheline, Thomas Tourdias, José V. Manjón, Pierrick Coupé A, Alzheimer’s Disease Neuroimaging Initiative, Michael Walter Weiner, Paul S. S Aisen, Ronald Carl Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel A. Beckett, , Randall Griffith

This study compares whole hippocampus and subfield biomarkers for Alzheimer’s disease detection and prediction using multimodal MRI data, finding subiculum biomarkers improve prediction accuracy.

Scientific Reports · Sep 25, 2019Peer-reviewedNeuroscience

Faster Cognitive Decline in Dementia due to Alzheimer Disease with Clinically Undiagnosed Lewy Body Disease

TG Beach, Michael Malek-Ahmadi, EDWARD Y. ZAMRINI, Charles H. Adler, Marwan Noel Sabbagh, Holly A. Shill, Sandra A. Jacobson, Christine M. Belden, Richard J. Caselli, B. K. Woodruff, Steven Z. Rapscak, Geoffrey L. Ahern, Jiong Shi, John N. Caviness, Erika D. Driver‐Dunckley, , Eric M. Reiman

This study compares cognitive decline rates in Alzheimer's disease with and without clinically undiagnosed Lewy body disease, finding faster decline in those with undiagnosed Lewy body disease.

PLoS ONE · Jun 25, 2019Peer-reviewedNeuroscience

A blood-based signature of cerebral spinal fluid Aβ1-42 status

Benjamin Goudey, Bowen John Fung, Christine Schieber, Noel Garry Faux, Michael Walter Weiner, Paul S. S. Aisen, Ronald Carl Petersen, Clifford R. Jack, William J. Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel A. Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, , Kyle B. Womack

This paper develops a blood-based machine learning model to predict cerebral spinal fluid Aβ1-42 levels, showing high accuracy in identifying Alzheimer's disease risk.

Scientific Reports · Mar 10, 2019Peer-reviewedNeuroscience