Alena Zı́ková

This study investigates the evolutionary and functional divergence of alternative oxidase (AOX) and AOX-like (AOX-L) proteins in trypanosomatids, revealing distinct origins and potential regulatory roles.

The paper identifies p22, a p32 family member, as essential for mitochondrial ribosome biogenesis in Trypanosoma brucei, revealing its dual role in RNA editing and mitoribosome assembly.

This study identifies three Oxa1 paralogs in Trypanosoma brucei and shows they have distinct roles in mitochondrial complex biogenesis.

The paper identifies proteolytic processing of the F1-ATPase subunit α in Trypanosoma brucei, showing that cleavage occurs in the cytosol before mitochondrial import.

The paper shows TbTim20 is critical for protein import under low membrane potential in trypanosomes lacking mitochondrial DNA.

The paper investigates the role of Mettl15 and Mettl17 in mitoribosome assembly, revealing their cooperative mechanism in transitioning from early to late stages of small subunit formation.

This study shows that ATP synthase reversal, regulated by TbIF1, is essential for Trypanosoma brucei differentiation between insect and mammalian hosts.

The paper reports cryo-EM structures of the ATP synthase dimer from Trypanosoma brucei, identifying an ancestral subunit-g/e module critical for oligomerization.