Vyacheslav Yurchenko

Argonaute loss is associated with reduced endogenous leishbuvirid RNA abundance and disruption of viral small RNA accumulation in Leishmania martiniquensis

The paper investigates the role of Argonaute in controlling viral replication in Leishmania martiniquensis, finding that its loss reduces viral RNA abundance and disrupts small RNA accumulation.

Alternative oxidase in trypanosomatids

This study investigates the evolutionary and functional divergence of alternative oxidase (AOX) and AOX-like (AOX-L) proteins in trypanosomatids, revealing distinct origins and potential regulatory roles.

Leishmania guyanensis controls endogenous viral replication by a canonical RNA interference pathway

This study identifies Dicer-like 1 and Argonaute 1 as critical for controlling viral RNA levels in Leishmania guyanensis via a canonical RNA interference pathway.

Life without heterotrimeric kinesins: trypanosomatids use a combination of homodimeric kinesin-2 motors to drive intraflagellar transport

This study shows trypanosomatids use homodimeric kinesin-2 motors KIN2A and KIN2B for intraflagellar transport, with KIN2B being essential and KIN2A having a more limited role.

A p32 family RNA editing factor acts in mitochondrial ribosome biogenesis

The paper identifies p22, a p32 family member, as essential for mitochondrial ribosome biogenesis in Trypanosoma brucei, revealing its dual role in RNA editing and mitoribosome assembly.

Uncovering parasite diversity in Ecuadorian wildlife: new trypanosomatid species and novel reservoir hosts for Leishmania amazonensis

The first RNA viruses detected in a trypanosome: novel narnaviruses and a leishmaniavirus in the gecko parasite Trypanosoma platydactyli

The paper identifies and characterizes the first RNA viruses in trypanosomes, including a leishmaniavirus and two narnaviruses in Trypanosoma platydactyli, suggesting ecological factors influence viral acquisition.

Genomic evidence for phylogenetic congruence with sporadic host shifts in leishmaniaviruses and their parasite hosts

This study investigates the co-phylogenetic history of Leishmania parasites and Leishmaniavirus, finding strong phylogenetic congruence at the subgenus and species level, with weaker signals in some cases due to intraspecific host switching.

Leishmania donovani GP63 paralogues cooperatively orchestrate visceral infection and persistence

This study identifies two essential GP63 paralogues in Leishmania donovani that cooperatively support visceral infection and persistence through distinct mechanisms.

Characterization of novel and essential kinetoplast-associated proteins in Trypanosoma brucei

This paper identifies and characterizes novel kinetoplast-associated proteins in Trypanosoma brucei, revealing their essential roles in mitochondrial DNA replication, segregation, and cell cycle regulation.

A novel nabelschnur protein regulates segregation of the kinetoplast DNA in Trypanosoma brucei

This paper identifies TbNAB70 as a protein essential for kinetoplast DNA segregation in Trypanosoma brucei, showing it binds to kDNA and facilitates its proper division.