Peggy A. O’Day

Down syndrome with Alzheimers disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis

The paper examines iron levels and lipid peroxidation in DSAD brains, finding increased iron and lipid damage compared to AD and controls, suggesting ferroptosis involvement.

Iron chelation by oral deferoxamine treatment decreased brain iron and iron signaling proteins

The paper shows oral DFO reduces brain iron and iron-related proteins in mice, suggesting potential therapeutic benefits for early-stage Alzheimer's.

Iron associated lipid peroxidation in Alzheimers disease is increased in lipid rafts with decreased ferroptosis suppressors, tested by chelation in mice

The paper investigates iron-mediated toxicity in Alzheimer's disease by analyzing postmortem brain tissue and ApoE4 mice, finding increased lipid peroxidation and decreased antioxidants in lipid rafts, which are reduced by iron chelation.