Author

Zhong Han

University of CopenhagenORCID 0000-0002-8705-1614Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Research Focus:transcription & RNA processing· 1 Approach:wet-lab / biochemical assay· 1 Organism:yeast· 1

Frequent Co-Authors

A. Barbara Dirac-SvejstrupiD· 2 shared Daniel BlearsiD· 2 shared Jesper Qualmann SvejstrupiD· 2 shared Agnieszka TudekiD· 1 shared Charlotte RusimbiiD· 1 shared David L. BentleyiD· 1 shared David Lopez Martinez· 1 shared David López MartíneziD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersCell Biology

A. Barbara Dirac-SvejstrupORCID

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3 papers

Recent·Most cited

Dynamic interaction between tentacle-tethered microdomains in Integrator and NELF regulates the promoter-proximal pause checkpoint

Daniel Blears, Pernille Bech, David Lopez Martinez, Pengfei Dai, Riyaz Shah, Nova Fong, Zhong Han, Richard Mitter, Ryan M. Sheridan, Jens Vilstrup Johansen, A. Barbara Dirac-Svejstrup, David L. Bentley, Jesper Qualmann Svejstrup

The paper identifies a direct interaction between Integrator and NELF that regulates transcriptional pausing and premature termination.

bioRxiv · Jul 1, 2026 · PreprintCell Biology

PAF1C allosterically activates CDK12/13 kinase during RNAPII transcript elongation

David López Martínez, Izabela Todorovski, Melvin Noé González, Charlotte Rusimbi, Daniel Blears, Nessrine Khallou, Zhong Han, A. Barbara Dirac-Svejstrup, Jesper Qualmann Svejstrup

The paper shows PAF1C allosterically activates CDK12/13 kinase to phosphorylate RNA polymerase II CTD during transcript elongation.

Molecular Cell · May 1, 2025Peer-reviewedMolecular Biology

Termination of non-coding transcription in yeast relies on both a CTD-interaction domain and a CTD-mimic in Sen1

Zhong Han, Olga Jasnovidova, Nouhou Haidara, Agnieszka Tudek, Karel Kubíček, Domenico Libri, Richard Štefl, Odil Porrúa

The paper identifies a CTD-mimic motif in Sen1 that interacts with Nrd1's CTD-interacting domain to facilitate ncRNA termination in yeast.

The EMBO Journal · Feb 28, 2020Peer-reviewedGenetics