Odil Porrúa

This study identifies distinct peripheral elements in senataxin that mediate R-loop unwinding and RNA polymerase II regulation through structural and biochemical analyses.

This study investigates how SETX mutations in ALS4 lead to RNA dysregulation and neuronal dysfunction through TGF-β signaling activation and R-loop metabolism disruption.

The paper investigates RNAPIII transcription termination in budding yeast, showing T-tracts are necessary but not sufficient, and secondary structures and Sen1 helicase are important for termination.

The paper identifies a phosphorylation event that modulates Sen1-mediated termination of non-coding transcription in budding yeast, leading to repression of downstream gene expression.

The paper identifies a CTD-mimic motif in Sen1 that interacts with Nrd1's CTD-interacting domain to facilitate ncRNA termination in yeast.