Jean‐Michel Peyrin

Microgravity stimulates network activity of 3D neuronal spheroids in an acoustic trap

The paper develops an acoustic bioreactor to study 3D neuronal spheroids in microgravity and finds increased calcium activity under microgravity conditions.

Scaffold-Free Acoustic Levitation Platforms Enable Scalable Culture of Neuronal Spheroids and Assembly of Layered Cortico - Striatal Assembloids

This paper introduces scaffold-free acoustic levitation platforms for culturing neuronal spheroids and assembling layered cortico-striatal assembloids, showing viability and functional maturation.

Modeling Huntington disease against age-related genes reveals CXXC4 as an epigenetic target to restore DRD1 striatal neuron activity

The paper identifies CXXC4 as an epigenetic target that can restore DRD1 striatal neuron activity in Huntington disease by leveraging age-related gene patterns.

Immune Cells Infiltration of Patient Derived Glioblastoma Cells spheroids in Acoustic Levitation in Bulk Acoustic Wave devices

The paper describes an acoustofluidic device for creating 3D tumoroids from patient-derived glioblastoma cells and shows immune cell infiltration in these tumoroids.

Quantitative study of alpha-synuclein prion-like spreading in fully oriented reconstructed neural networks reveals non-synaptic dissemination of seeding aggregates

This study uses a novel microfluidic system to investigate how alpha-synuclein aggregates spread between neurons, finding that synaptic connectivity does not significantly affect transfer efficiency.