Author

Jeff Aaronson

CHDI Foundation

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jim Rosinski· 3 shared Christian NériiD· 2 shared Lucile MégretiD· 2 shared Alberto Ambesi‐ImpiombatoiD· 1 shared Brenda Lager· 1 shared Christopher HartliD· 1 shared Cloé Mendoza· 1 shared Daniela BrunneriD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersNeuroscience

Jim Rosinski

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Modeling Huntington disease against age-related genes reveals CXXC4 as an epigenetic target to restore DRD1 striatal neuron activity

M. Arrieta, Francesca Farina, Tamara Monteagudo Aboy, Megan L. Mair, Cloé Mendoza, Huy Tran, Jeff Aaronson, Jim Rosinski, Lisa Ellerby, Emmanuel Brouillet, Jean‐Michel Peyrin, Juan Botas, Christian Néri, Lucile Mégret

The paper identifies CXXC4 as an epigenetic target that can restore DRD1 striatal neuron activity in Huntington disease by leveraging age-related gene patterns.

bioRxiv · Jan 13, 2026 · PreprintNeuroscience

Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model

Deanna M. Marchionini, Jeh-Ping Liu, Alberto Ambesi‐Impiombato, Kimberly Kerker, Kim Cirillo, Mukesh Bansal, Rich Mushlin, Daniela Brunner, Sylvie Ramboz, Mei Yee Kwan, Kirsten Kuhlbrodt, Karsten Tillack, Finn Peters, Leena Rauhala, John C. Obenauer, , Scott O. Zeitlin

This study shows that moderate global lowering of mutant Huntingtin in a HD mouse model delays some deficits but benefits diminish over time, suggesting long-term mHtt lowering may be needed for sustained benefit.

JCI Insight · Oct 23, 2022Peer-reviewedNeuroscience

Combining feature selection and shape analysis uncovers precise rules for miRNA regulation in Huntington's disease mice

Lucile Mégret, Satish Sasidharan Nair, Julia Dancourt, Jeff Aaronson, Jim Rosinski, Christian Néri

The paper introduces miRAMINT, a method combining feature selection and shape analysis to identify miRNA-mRNA pairs in HD mice, revealing 31 precise regulatory relationships in striatum.

BMC Bioinformatics · Feb 24, 2020Peer-reviewedBioinformatics