Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes
Maëva Devoucoux, Victoire Fort, Gabriel Khelifi, Joshua Xu, Nader Alerasool, Maxime Galloy, Nicholas Wong, Gaëlle Bourriquen, Amélie Fradet‐Turcotte, Mikko Taipale, Kristin J. Hope, Samer M. I. Hussein, Jacques Côté
This paper characterizes the ZMYND11-MBTD1 fusion protein's role in oncogenesis by mislocalizing the NuA4/TIP60 complex to gene bodies, altering transcription and splicing, particularly of the MYC oncogene.
Cell Reports · Jun 1, 2022Peer-reviewedMolecular Biology