Samer M. I. Hussein

Long-read RNA sequencing identifies non-coding isoform switching as a regulator of cell fate

The paper uses long-read RNA sequencing to identify non-coding isoform switching that regulates cell fate during reprogramming.

LncRNA-mediated organization of oncogenic chromatin state is a targetable vulnerability in leukemia

This study identifies PAN3-AS1 as an oncogenic lncRNA in AML, shows its role in chromatin organization, and demonstrates RNA-targeting LNP therapy to reduce leukemia burden.

ZNF768 regulates expression of E2F1 protein to drive G0/G1 transition and cell cycle progression.

This study identifies ZNF768 as a regulator of E2F1 expression, which drives G0/G1 transition and cell cycle progression, with implications for cancer progression.

Matrix Stiffness-driven FAK Splicing Tunes Cell Mechanosensing

This study identifies a FAK isoform, FAK{Delta}e4, regulated by matrix stiffness, which influences cell migration, invasion, and mechanosensing.

Snhg26 long non-coding RNA regulates pluripotent cell states through a SINEB2-derived sequence

This study identifies Snhg26 lncRNA's role in regulating pluripotent cell states through a SINEB2-derived sequence, showing its interaction with transposable elements.

Axon-specific mRNA translation shapes dopaminergic circuit development

The paper identifies axon-specific mRNA translation in dopaminergic neurons and shows how it regulates axon development and connectivity.

Concomitant acetylation and loading of H2A.Z by NuA4/TIP60 regulate target gene transcription

This study investigates how NuA4/TIP60 complex acetylates and loads H2A.Z onto chromatin to regulate transcription, showing that acetylation precedes chromatin incorporation at promoters.

Glioblastoma gene expression-based subtypes have defined metabolomic states

The paper identifies metabolomic differences between mesenchymal and proneural GBM subtypes using cell lines and metabolomic analyses.

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

This paper characterizes the ZMYND11-MBTD1 fusion protein's role in oncogenesis by mislocalizing the NuA4/TIP60 complex to gene bodies, altering transcription and splicing, particularly of the MYC oncogene.

MRG proteins are shared by multiple protein complexes with distinct functions

The paper identifies and characterizes multiple protein complexes associated with MRG15 and MRGX, revealing their roles in chromatin modification and transcription regulation.

Signal requirement for cortical potential of transplantable human neuroepithelial stem cells

This study identifies six signaling pathways regulating the proliferation and developmental potential of human neuroepithelial stem cells in vitro.