Author

Roy D. Missall

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:GWAS / association mapping· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

Lot D. de WitteiD· 5 shared Raphael KübleriD· 4 shared Frederieke A. J. GigaseiD· 3 shared Towfique RajiD· 3 shared Alice BuonfiglioliiD· 2 shared Daniele MatteiiD· 2 shared Gijsje J. L. SnijdersiD· 2 shared Jack HumphreyiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersNeuroscience

Lot D. de WitteORCID

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Author profile →

5 papers

Recent·Most cited

Parkinson's disease genetic risk converges on Lewy body pathology-associated microglial states

Raphael Kübler, Daniele Mattei, Josep Oriol Narcís, Claudia De Sanctis, Kosei Hirata, Alice Buonfiglioli, Ariana Chriss, Mikaela Rosen Perez, Felix A. Crary, Emma L Thorn, Alex Tokolyi, Tarek Khashan, Roy D. Missall, Beomjin Jang, Kailash BP, , Towfique Raj

The paper identifies microglial states associated with Parkinson's disease genetic risk and Lewy body pathology using single-cell profiling and integrates data with AMP PD.

medRxiv · Oct 28, 2026 · PreprintGenetic & Genomic Medicine

The human microglia responsome: a resource to better understand microglia states in health and disease

Gijsje J. L. Snijders, Kátia de Paiva Lopes, Marjolein A. M. Sneeboer, Benjamin Z. Muller, Frederieke A. J. Gigase, Dante D’Urso, Ricardo A. Vialle, Roy D. Missall, Raphael Kübler, Towfique Raj, Jack Humphrey, Lot D. de Witte

The paper characterizes the human microglia responsome by analyzing gene expression in microglia exposed to various stimuli, identifying distinct responses and genetic interactions relevant to disease.

Brain Behavior and Immunity · Sep 1, 2025Peer-reviewedNeuroscience

A microglia-containing cerebral organoid model to study early life immune challenges

Alice Buonfiglioli, Raphael Kübler, Roy D. Missall, Renske de Jong, Stephanie Chan, Verena Claudia Haage, Stefan Wendt, Ada J. Lin, Daniele Mattei, Mara Graziani, Brooke L. Latour, Frederieke A. J. Gigase, Rebecca Chiu, Ya Zhang, Haakon B. Nygaard, , Lot D. de Witte

This paper introduces a cerebral organoid model with integrated microglia to study how inflammatory stimuli and microglial presence affect neurodevelopment and neurodevelopmental disorders.

bioRxiv · May 24, 2024Neuroscience

HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model

Alice K. Min, Behnam Javidfar, Roy D. Missall, Donald Doanman, Madel Durens, Samantha St Vil, Zahra Masih, Mara Graziani, Annika Mordelt, Samuele G. Marro, Lot D. de Witte, Benjamin K. Chen, Talia H. Swartz, Schahram Akbarian

This paper describes a humanized mouse model using iPSC-derived microglia to study HIV-1 infection in the CNS, enabling genetic and therapeutic investigations in vivo.

Journal of Virology · Nov 30, 2023Peer-reviewedNeuroscience

Atlas of genetic effects in human microglia transcriptome across brain regions, aging and disease pathologies

Kátia de Paiva Lopes, Gijsje J. L. Snijders, Jack Humphrey, Amanda Allan, Marjolein A. M. Sneeboer, Elisa Navarro, Brian M. Schilder, Ricardo A. Vialle, Madison Parks, Roy D. Missall, Welmoed van Zuiden, Frederieke A. J. Gigase, Raphael Kübler, Amber Berdenis van Berlekom, Emily M. Hicks, , Towfique Raj

The paper analyzes the transcriptome of human microglia across brain regions, aging, and disease to identify genetic effects on gene expression and splicing, linking them to neurological disorders.

Nature Genetics · Jan 1, 2022Peer-reviewedGenetics