ATRX Loss Predicts Poor Outcomes and Reveals a Therapeutic Vulnerability to TEAD Inhibition in Soft Tissue Sarcomas
Ryan A. Denu, Anand Kamal Singh, Yingda Jiang, Zhao Zheng, Davis R. Ingram, Khalida Wani, Rossana Lazcano, Madison P. Ginn, Kumaren Anand, Bishal K. Singh, Jackson C. Ballard, Veena Kochat, Biji Chatterjee, William I. Padron, Sharon M. Landers, , Kunal Rai
This study shows ATRX loss in sarcomas correlates with poor outcomes and identifies TEAD inhibition as a potential therapy for ATRX-deficient tumors.
bioRxiv · Nov 23, 2025 · PreprintCancer Biology