R. Brad Jones

HIV-1 Integration Site Determines the Transcriptional Fate and Persistence of Integrated Proviruses

This study investigates how HIV-1 integration sites influence viral latency and clonal expansion in human memory CD4+ T cells engrafted into mice.

PRISM-Seq: An Ultra-sensitive Sequencing Approach For Mapping Lentiviral Integration Sites

PRISM-seq is an ultra-sensitive method for detecting lentiviral integration sites, validated at the single-molecule level with a quality control framework to reduce artifacts.

A Transcriptional Signature of Induced Neurons Differentiates Virologically Suppressed People Living With HIV from People Without HIV

Direct reprogramming of skin fibroblasts into neurons reveals unique gene signatures indicative of HIV infection in the context of viral suppression.

HIV-1 expression is heterogeneous among clones of CD4+ T cells carrying authentic intact latent proviruses

The paper examines HIV-1 expression in CD4+ T cell clones with latent proviruses, finding heterogeneous expression and limited response to latency reversing agents.

Q4ddPCR (May the Fourth Be Precise): A Flexible, 4-Target Assay for High-Resolution HIV Reservoir Profiling

Q4ddPCR improves HIV reservoir quantification by targeting four conserved regions, achieving 95% accuracy and revealing clonal dynamics not detectable by IPDA.

The EZH2 inhibitor tazemetostat mitigates HIV immune evasion, reduces reservoir formation, and promotes durable CD8+ T-cell revitalization

The paper shows that tazemetostat reduces HIV reservoirs and improves CD8+ T-cell function by increasing MHC-I expression and promoting anti-HIV immune responses.

Multi-Omic Atlas reveals cytotoxic phenotype and ROS-linked metabolic quiescence as key features of CTL-resistant HIV-infected CD4+ T-cells