Ilaria Chiaradia

Multi-omic analysis of guided and unguided forebrain organoids reveal differences in cellular composition and metabolic profiles

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.

Human-specific morphoregulatory signatures in basal radial glia characterize neocortex evolution

This study identifies human-specific morphoregulatory signatures in basal radial glia that drive neocortex evolution through comparative chromatin and transcriptional profiling.

Calcium dynamics tune timing of developmental transitions to generate evolutionarily divergent axon tract lengths

The paper shows that slower axon growth in humans, driven by reduced calcium influx, leads to longer axon tracts through prolonged growth duration, with calcium dynamics regulating developmental timing.

Male sex hormones increase excitatory neuron production in developing human neocortex

This study uses brain organoids to show that male sex hormones increase excitatory neuron production in the human neocortex by enhancing progenitor proliferation and affecting chromatin remodeling.