Sreekar Mantena

The paper maps common TCR alleles in 2,668 donors, finds natural selection on TRAJ and TRAV genes, and shows allelic polymorphism affects T cell function.

This paper develops a CRISPR-based assay for rapid detection of cefixime resistance in Neisseria gonorrhoeae by analyzing penA gene mosaicism.

This paper designs artificial CRISPR-Cas13a guide RNAs using model-directed algorithms, showing improved sensitivity and variant discrimination in nucleic acid detection.

This paper designs viral diagnostics using a model-based optimization approach, achieving higher sensitivity and specificity across viral genomic variation.