Eliza Thulson

Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk

The paper identifies OA risk genes by integrating eQTLs, chromatin accessibility, and 3D chromatin structure in human chondrocytes, revealing 13 putative risk genes, 10 of which are novel.

Response splicing QTLs in primary human chondrocytes identifies putative osteoarthritis risk genes

The paper identifies response splicing QTLs in human chondrocytes and links them to osteoarthritis risk genes through alternative splicing analysis.

Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription

The paper analyzes temporal changes in chromatin structure and gene expression during macrophage activation, finding a reciprocal relationship between loops and transcription.

3D Chromatin Structure in Chondrocytes Identifies Putative Osteoarthritis Risk Genes

The paper identifies 56 putative OA risk genes by integrating GWAS, chromatin structure, and RNA-seq data in chondrocytes, with SOCS2 as a novel target gene.

A piggyBac-based toolkit for inducible genome editing in mammalian cells

The paper introduces CRISPR-Bac, a piggyBac-based system for inducible CRISPR-Cas9 genome editing in mammalian cells, enabling efficient gene knockdown, deletion, and transcriptional activation/repression.