Author

Seth D. Greengo

Johns Hopkins UniversityORCID 0000-0002-8912-7782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Arturo CasadevalliD· 4 shared Quigly DragotakesiD· 3 shared Gracen R. GerbigiD· 2 shared Maggie P. WeariD· 2 shared Piotr R. StempinskiiD· 2 shared Alan Xu· 1 shared Amanda DziedziciD· 1 shared Ananya Majumdar· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersMicrobiology

Arturo CasadevallORCID

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Author profile →

5 papers

Recent·Most cited

Inhibitors of spore germination act against diverse human fungal pathogens

Jacqueline A Spieles, Seth D. Greengo, Ashley M. Holt, Madison C Barnes, Nancy P. Keller, Jeniel E. Nett, Christina M. Hull

The paper evaluates 191 small molecule inhibitors of Cryptococcus germination for their activity against other fungal pathogens and human cell toxicity, identifying 101 with therapeutic potential.

bioRxiv · Sep 16, 2026 · PreprintMicrobiology

Commonalities and differences in the Cryptococcus neoformans response to ingestion by protozoal and mammalian phagocytic cells suggests host cell metabolism as a target for intracellular survival

Quigly Dragotakes, Ella Jacobs, Gracen R. Gerbig, Seth D. Greengo, Anne Jedlicka, Amanda Dziedzic, Arturo Casadevall

This study isolates and characterizes cryptococcal phagosomes from different host cells, revealing conserved fungal responses and suggesting host metabolism as a target for survival.

PLoS Pathogens · Dec 26, 2025Peer-reviewedMicrobiology

The buoyancy of cryptococcal cells and its implications for transport and persistence of Cryptococcus in aqueous environments

Isabel Angelica Jimenez, Piotr R. Stempinski, Quigly Dragotakes, Seth D. Greengo, L. R. Sanchez Ramirez, Arturo Casadevall

This paper investigates how salinity and polysaccharide rafts affect the buoyancy and persistence of Cryptococcus cells in water, with implications for their transport and pathogenic potential.

mSphere · Nov 27, 2024Peer-reviewedMicrobiology

On the relationship between serotype, chemotype and genotype for Cryptococcus spp. including a method for including polysaccharide structure in strain characterization

Maggie P. Wear, Seth D. Greengo, Scott McConnell, Alan Xu, Livia Liporagi Lopes, Ananya Majumdar, Arturo Casadevall

This paper examines the relationship between serotype, chemotype, and genotype in Cryptococcus spp., finding no strong correlation between these classifications and GXM motif expression, and introduces a new method for polysaccharide characterization.

bioRxiv · Aug 22, 2024 · PreprintMicrobiology

Human and murine Cryptococcus neoformans infection selects for common genomic changes in an environmental isolate.

Poppy Sephton-Clark, Scott A. McConnell, Nina T. Grossman, Rosanna P. Baker, Quigly Dragotakes, Yunfan Fan, Man Shun Fu, Gracen R. Gerbig, Seth D. Greengo, J. Marie Hardwick, Madhura Kulkarni, Stuart M. Levitz, Joshua Daniel Nosanchuk, Shmuel Shoham, Daniel F. Q. Smith, , Arturo Casadevall

The paper shows that environmental Cryptococcus neoformans strains undergo genomic and phenotypic changes during mammalian infection, suggesting animal virulence drives genetic adaptation.

bioRxiv · Apr 12, 2022 · PreprintGenomics