Nancy P. Keller

Endosome motility controls light-responsive reproductive development and secondary metabolite production in Aspergillus

This study shows that endosome motility in Aspergillus species affects light-responsive development and secondary metabolite production.

Inhibitors of spore germination act against diverse human fungal pathogens

The paper evaluates 191 small molecule inhibitors of Cryptococcus germination for their activity against other fungal pathogens and human cell toxicity, identifying 101 with therapeutic potential.

The Aspergillus fumigatus C2-Domain Protein SppA is required for septal integrity and alters susceptibility to echinocandins and neutrophil killing during infection

This paper identifies SppA as a critical protein for septal integrity in A. fumigatus, showing its role in antifungal tolerance and virulence.

Aneuploidy promotes transient stress adaptation and metabolic flexibility in the human fungal pathogen Aspergillus fumigatus

This paper shows that aneuploidy in A. fumigatus enhances stress adaptation and metabolic flexibility, particularly in response to FK506 and voriconazole.

An Aspergillus lncRNA atlas reveals a novel modulator of aflatoxin biosynthesis

The paper constructs an Aspergillus lncRNA atlas, identifies a novel lncRNA that modulates aflatoxin biosynthesis, and shows its deletion reduces aflatoxin production.

A network-based model of Aspergillus fumigatus elucidates regulators of development and defensive natural products of an opportunistic pathogen

This paper constructs a gene regulatory network for Aspergillus fumigatus using RNA-seq data, validates it with experimental cases, and provides an online resource called GRAsp.

Population-Specific Transcriptomic Shifts Underlie Secondary Metabolic Diversification in Aspergillus flavus and the Domestication of Aspergillus oryzae

This paper identifies population-specific transcriptomic shifts in Aspergillus species, showing how transcriptomic reorganization drives secondary metabolic diversification and domestication in A. oryzae.

Pathogenicity is associated with population structure in a fungal pathogen of humans

The paper analyzes genomic data from 250 Aspergillus flavus isolates to show that pathogenicity is strongly linked to population structure, with population D containing most clinical isolates and harboring genes related to zinc ion binding and lipid metabolism.

Zebrafish larval GPR132b differentially influences wound repair and infection control

This study shows that GPR132b in zebrafish affects wound healing and infection resistance by modulating macrophage activity and lipid signaling pathways.

A conserved in vivo burn wound infection model for diverse pathogenic fungi.

This paper establishes a zebrafish burn wound model to study fungal colonization and host immune responses, finding that macrophages and neutrophils control fungal infection with some redundancy.

GATA1-deficient human pluripotent stem cells generate neutrophils with improved antifungal immunity that is mediated by the integrin CD18

This study shows that GATA1-deficient iPSC-derived neutrophils have enhanced antifungal activity against Aspergillus fumigatus, mediated by CD18 integrin.

A guidance into the fungal metabolomic abyss: Network analysis for revealing relationships between exogenous compounds and their outputs

The paper introduces network analysis methods to identify exogenous compounds that trigger specialized metabolite production in fungi and distinguish unknown analytes.

Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species

This study identifies five types of genetic variation in secondary metabolic gene clusters across 66 strains of Aspergillus fumigatus and links them to evolutionary drivers like mutation, recombination, and horizontal gene transfer.