The paper evaluates how glycan-binding proteins and immune cells recognize mirror-image glycans, finding widespread binding and donor-specific recognition of L-glycans.

bioRxiv · Jul 20, 2026 · PreprintBiochemistry

Intelectin-2 is a broad-spectrum antimicrobial lectin

Amanda E. Dugan, Deepsing Syangtan, Eric B. Nonnecke, Rajeev S. Chorghade, Amanda L. Peiffer, Jenny J. Yao, Jessica Ille-Bunn, Dallis Sergio, Gleb Pishchany, Catherine Dhennezel, Hera C. Vlamakis, Sunhee Bae, Sheila E. Johnson, Chariesse Ellis, Soumi Ghosh, , Laura L. Kiessling

This study identifies intelectin-2 as an antimicrobial lectin that crosslinks mucins and kills microbes by binding glycans in mucus.

Nature Communications · Jan 13, 2026Peer-reviewedMicrobiology

Glycan analysis probes inspired by human lectins for investigating host-microbe crosstalk

Soumi Ghosh, Rajeev S. Chorghade, Roger C. Diehl, Greg J. Dodge, Sunhee Bae, Amanda E. Dugan, Melanie Halim, Michael G. Wuo, Helen Bartlett, Liam K. Herndon, Laura L. Kiessling, Barbara Imperiali

The paper introduces glycan analysis probes (GAPs) inspired by human lectins to study host-microbe interactions and glycan-mediated processes.

Glycobiology · May 27, 2025Peer-reviewedBiochemistry