Kieran O. Russell

Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation

This study introduces OpenCGChromatin, a model that simulates chromatin structure and phase separation, revealing how linker-DNA length and histone modifications affect chromatin organization.

A Spectrum of Free Energy Landscape Topologies Encodes Chromatin Polymorphism and Phase Separation

This paper maps the free-energy landscapes of chromatin structures and shows how linker DNA geometry and sequence modulate their topologies, influencing phase separation and structural polymorphism.

Multi-scale structure of chromatin condensates rationalizes phase separation and material properties

The paper investigates the structure of chromatin condensates across scales and shows how nucleosome arrangement and histone interactions influence their physical properties.

Chemically-informed coarse-graining of electrostatic forces in charge-richbiomolecular condensates

The paper introduces Mpipi-Recharged, a coarse-grained model that improves electrostatic force description in charge-rich biomolecular condensates by incorporating asymmetric potentials from atomistic simulations.