Yoshiho Ikeuchi

Repetitive stimulation modifies network characteristics of neural organoid circuits

This study shows that three-organoid networks exhibit better stimulus decoding after repetitive stimulation compared to smaller networks.

BioemuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic SpikingNeural Network

The paper introduces BioemuS, a real-time biomimetic spiking neural network system for biohybrid experiments and emulation, aiming to advance neuroprosthetic development.

MeCP2 Represses the Activity of Topoisomerase IIβ in Long Neuronal Genes

This study identifies a functional interaction between MeCP2 and TOP2β in neurons, showing MeCP2 inhibits TOP2β activity at long genes, which may contribute to neurodevelopmental disorders.

Absolute calibration of ribosome profiling assesses the dynamics of ribosomal flux on transcripts

This paper introduces methods to absolute quantify ribosome flux on transcripts, revealing ribosome allocation under stress, aging, and across cell types.

ARID1B controls transcriptional programs of axon projection in the human corpus callosum

This study identifies ARID1B's role in axon projection of callosal projection neurons, showing its haploinsufficiency leads to structural underconnectivity and agenesis of the corpus callosum.

Mito-FUNCAT-FACS reveals cellular heterogeneity in mitochondrial translation

The paper develops mito-FUNCAT-FACS to measure mitochondrial translation activity in individual cells and detects heterogeneity in cancer cells.

eIF2B-capturing viral protein NSs suppresses the integrated stress response

This study identifies SFSV NSs as a viral protein that suppresses the integrated stress response by binding to eIF2B and preventing eIF2(P) from inhibiting nucleotide exchange.

Advanced Complexity and Plasticity of Neural Activity in Reciprocally Connected Human Cerebral Organoids

This study shows that reciprocally connected human cerebral organoids exhibit more complex and plastic neural activity compared to conventional organoids.

A widespread family of heat-resistant obscure (Hero) proteins protect against protein instability and aggregation

This study identifies Hero proteins as heat-resistant proteins that stabilize other proteins and prevent aggregation, extending lifespan in Drosophila.