Nelly M. Cruz

Intermolecular 3'UTR-3'UTR interactions drive Wnt gene activation through heteromeric protein assembly

The paper shows that 3'UTR-3'UTR interactions drive Wnt gene activation by enabling co-translational protein complex assembly, independent of protein abundance.

Identifying in vivo genetic dependencies of melanocyte and melanoma development

This study uses a zebrafish model to identify genetic dependencies in melanocyte and melanoma development, revealing that gene loss can paradoxically promote aggressive phenotypes.

Receptor tyrosine kinase inhibition leads to regression of acral melanoma by targeting the tumor microenvironment

This study shows that dual FGFR/VEGFR inhibition causes regression of acral melanoma by targeting the tumor microenvironment rather than directly killing cancer cells.