Yilun Ma

Restraint of melanoma progression by cells in the local skin environment

The paper shows that keratinocyte EMT-like transformation in melanoma reduces tumor invasion and improves survival through altered cell-cell interactions.

Identifying in vivo genetic dependencies of melanocyte and melanoma development

This study uses a zebrafish model to identify genetic dependencies in melanocyte and melanoma development, revealing that gene loss can paradoxically promote aggressive phenotypes.

The lipid droplet protein DHRS3 is a regulator of melanoma cell state

The paper identifies DHRS3 as a lipid droplet protein that regulates melanoma cell state by modulating retinoid signaling.

A global atlas of substrate specificities for the human serine/threonine kinome

Positional scanning peptide arrays profile substrate sequence specificities across 303 human serine/threonine kinases, enabling computational kinase-substrate annotation and signaling pathway inference across the human phosphoproteome.

Inducible and reversible inhibition of miRNA-mediated gene repression in vivo

This study develops a genetic tool to reversibly inhibit miRNA-mediated gene repression in vivo and shows tissue-specific dependencies on miRNA function for homeostasis and regeneration.