Author

Brian A. Lanman

Amgen (United States)ORCID 0000-0002-8768-7188Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Anh T. Tran· 1 shared Arghya Sadhukhan· 1 shared Chris Wilde· 1 shared Christopher E. SmithiD· 1 shared Dhanusha A. NalawanshaiD· 1 shared Felipe de Sousa e MeloiD· 1 shared Georgios Mazis· 1 shared Gitte Husemoen· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Anh T. Tran

Mutual co-authors in cluster

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1 paper

Recent·Most cited

LYMTACs: Chimeric Small Molecules Repurpose Lysosomal Membrane Proteins for Target Protein Relocalization and Degradation

Dhanusha A. Nalawansha, Georgios Mazis, Gitte Husemoen, Kate S. Ashton, Weixian Deng, Ryan P. Wurz, Anh T. Tran, Brian A. Lanman, Jiansong Xie, Robert G. Guenette, Shiqian Li, Christopher E. Smith, Suresh Archunan, Manoj K. Agnihotram, Arghya Sadhukhan, , Patrick Ryan Potts

This paper introduces LYMTACs, small molecules that use lysosomal membrane proteins to target and degrade membrane proteins, showing effectiveness against KRASG12D.

Nature Communications · Aug 21, 2025Peer-reviewedCancer Biology