Author

Melissa J. Asher

University of MichiganORCID 0000-0002-9074-557XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Amy Krans· 2 shared Peter K. ToddiD· 2 shared Samantha GrudzieniD· 2 shared Sydney WilleyiD· 2 shared Adrian M. IsaacsiD· 1 shared Alain NdayisabaiD· 1 shared Alan P. BoyleiD· 1 shared Amanda L. GarneriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersNeuroscience

Amy Krans

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Altered neuronal start codon stringency favors cap-independent repeat-associated non-AUG translation

Clare M. Wieland, Shannon E. Wright, Sydney Willey, Ishita Purwar, Samantha Grudzien, Amy Krans, Erinn L. Laimon-Thomson, Melissa J. Asher, Adrian M. Isaacs, Amanda L. Garner, Peter K. Todd

The paper shows that neurons prefer cap-independent RAN translation from specific repeats, linked to altered start codon stringency and eIF1 redistribution.

Nucleic Acids Research · Sep 7, 2026Peer-reviewedNeuroscience

AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons

Connor J. Maltby, Amy Krans, Samantha Grudzien, Yomira Palacios, Jessica Muiños, Andrea Suárez, Melissa J. Asher, Sydney Willey, Kinsey Van Deynze, Camille Mumm, Alan P. Boyle, Andrea Cortese, Alain Ndayisaba, Vikram Khurana, Sami J. Barmada, , Peter K. Todd

This study shows that AAGGG repeat expansions cause synaptic defects in CANVAS neurons independently of RFC1, with phenotypes corrected by repeat deletion.

Science Advances · Sep 4, 2024Peer-reviewedNeuroscience