Déborah Bourc’his

The paper identifies transposable element insertions that repurpose immune endonucleases to cause hybrid embryo death in mice, contributing to reproductive isolation.

The paper introduces OneCell CUT&Tag, a single-cell multi-omics method that captures chromatin, transcriptome, and surface marker data, revealing epigenomic reprogramming during mammary gland basal-to-luminal transition.

The paper maps X-linked gene reactivation and epigenetic silencing in developing PGCs, showing partial resistance to reactivation and enrichment of repressive marks.

This study shows that DNA methylation is critical for restricting neural differentiation but not germline fate in ESCs, with TKO ESCs capable of germline specification.

The paper uses multi-omics analysis to compare malignant and normal uveal melanocytes, identifying genomic instability and a BAP1 promoter deletion as key features of uveal melanoma.

This study uses single-embryo transcriptomics to assess how different IVF culture media affect gene expression in human preimplantation embryos, showing medium-specific effects that diminish by the blastocyst stage.

The paper identifies H3K9me3 at the Nanog locus as a repressive mark that marks differentiation commitment and enables primitive endoderm fate acquisition in ES cells.

This study shows that DNMT3A-dependent DNA methylation is essential for spermatogonial stem cells to commit to differentiation and spermatogenesis.

This study shows that the imprinted Zdbf2 gene is critical for neonatal growth and feeding adaptation in mice, with loss of function leading to poor survival and reduced body weight.

This study identifies EZHIP as a novel cofactor of PRC2 that limits its activity in germ cells, leading to altered H3K27me2/3 deposition and impaired fertility in female mice.

The paper shows that CTCF-mediated enhancer partitioning controls the promoter switch of Zdbf2 during exit from naïve pluripotency, independent of polycomb and DNA methylation.