Jan Kadlec

The dual trxG/PcG protein ULTRAPETALA1 modulates H3K27me3 and directly enhances POLYCOMB REPRESSIVE COMPLEX 2 activity for fine-tuned reproductive transitions

This study shows ULTRAPETALA1 modulates PRC2 activity and enhances H3K27me3 deposition in Arabidopsis, revealing a bivalent trxG/PcG factor mechanism for chromatin regulation.

ULTRAPETALA1 remodels PRC2 recruitment to nucleosomes

The paper identifies a plant-specific PRC2 variant, PRC2.3, which uses ULTRAPETALA1 to target nucleosomes and deposit H3K27me3 at developmental genes.

KDM7B-mediated demethylation of RNF113A regulates small cell lung cancer sensitivity to alkylation damage

This study identifies KDM7B as a demethylase that regulates RNF113A, affecting DNA repair and chemoresistance in small cell lung cancer.

Structural basis for the synergistic assembly of the snRNA export complex

This study presents the cryo-EM structure of the snRNA export complex and shows how PHAX synergistically binds components to facilitate snRNA export.

TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks

This study shows that the TOPOVIBL-REC114 interaction is essential for the efficiency and timing of meiotic DNA double-strand breaks in mice.

Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4