Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human macrophages in the presence of TLR stimulation
Wei Wang, Alesja Dernst, Bianca Martin, Lucía Lorenzi, Maria Cadefau-Fabregat, Kshiti Meera Phulphagar, Antonia Wagener, Christina F. Budden, Neil Stair, Theresa Maria Wagner, Harald Andreas Färber, Andreas Jaensch, Rainer Stahl, Fraser Duthie, Susanne V. Schmidt, , M. S. J. Mangan
The paper shows that butyrate and propionate activate the NLRP3 inflammasome in human macrophages when combined with TLR agonists, through HDAC inhibition and epigenetic changes.
Cell Reports · Sep 1, 2024Peer-reviewedImmunology