Author

Vikas Kaushik

Saint Louis UniversityORCID 0000-0001-6629-7693Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

Edwin AntonyiD· 5 shared Brian B. BothneriD· 3 shared Jaigeeth DeveryshettyiD· 3 shared Sofia S. OrigantiiD· 3 shared Abhinav VayyetiiD· 2 shared Ayush MistryiD· 2 shared Monika Tokmina‐LukaszewskaiD· 2 shared Rahul ChaddaiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersBiochemistry

Edwin AntonyORCID

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Author profile →

5 papers

Recent·Most cited

A Phosphorylation Switch Modulates Configurational Codes in the Oncofetal IGF2BP RNA Binding Paralogs

Vikas Kaushik, Vaishnavi Sanjayan, Jenna R. Mattice, Monika Tokmina‐Lukaszewska, Ricarda Törner, Ilan Edelstein, Rahul Chadda, R. P. KASHYAP, Abhinav Vayyeti, Pralambika Roy, Ryan A. Mehl, Richard B. Cooley, Snorri Th. Sigurdsson, Yaakov Levy, Reza Dastvan, , Edwin Antony

This study shows phosphorylation of IGF2BP1 and IGF2BP3 at a conserved serine acts as a configurational switch, altering their RNA binding domain arrangements and affecting mRNA regulation.

bioRxiv · Aug 19, 2026 · PreprintBiochemistry

PCNA encircling primer/template junctions is eliminated by exchange of RPA for Rad51: Implications for the interplay between human DNA damage tolerance pathways

Jessica L. Norris, Lindsey O. Rogers, Grace Young, Kara G Pytko, Rachel L. Dannenberg, Samuel Perreault, Vikas Kaushik, Edwin Antony, Mark Hedglin

This study investigates the interplay between DNA damage tolerance pathways by comparing PCNA occupancy and RPA/Rad51 exchange at stalled replication sites.

Nucleic Acids Research · Dec 17, 2025Peer-reviewedBiophysics

Mechanism of RPA phosphocode priming and tuning by Cdk1/Wee1 signaling circuit

Poonam Roshan, Vikas Kaushik, Ayush Mistry, Abhinav Vayyeti, Aidan Antony, Riley Luebbers, Jaigeeth Deveryshetty, Edwin Antony, Sofia S. Origanti

This study identifies a feedback mechanism involving Cdk1/Wee1 signaling that primes and tunes RPA phosphorylation, crucial for cell cycle progression and DNA damage response.

Nature Communications · Dec 9, 2025Peer-reviewedBiochemistry

Rad52 sorts and stacks Rad51 at the DNA junction to promote homologous recombination

Jaigeeth Deveryshetty, Ayush Mistry, Sushil Pangeni, Mohamed Ghoneim, Monika Tokmina‐Lukaszewska, Vikas Kaushik, Angela Taddei, Taekjip Ha, Brian B. Bothner, Edwin Antony

This study reveals how Rad52 sorts and stacks Rad51 at DNA junctions to enhance homologous recombination by promoting Rad51 binding to RPA-coated ssDNA.

bioRxiv · Nov 7, 2024 · PreprintBiochemistry

Wrapping of single-stranded DNA by Replication Protein A and modulation through phosphorylation

Rahul Chadda, Vikas Kaushik, Iram M. Ahmad, Jaigeeth Deveryshetty, Alex S. Holehouse, Snorri Th. Sigurdsson, Gargi Biswas, Yaakov Levy, Brian B. Bothner, Richard B. Cooley, Ryan A. Mehl, Reza Dastvan, Sofia S. Origanti, Edwin Antony

This study uses single-molecule techniques to show that RPA partially wraps ssDNA and that phosphorylation at Ser-384 modulates this wrapping.

Nucleic Acids Research · Jun 25, 2024Peer-reviewedBiochemistry