A Phosphorylation Switch Modulates Configurational Codes in the Oncofetal IGF2BP RNA Binding Paralogs
Vikas Kaushik, Vaishnavi Sanjayan, Jenna R. Mattice, Monika Tokmina‐Lukaszewska, Ricarda Törner, Ilan Edelstein, Rahul Chadda, R. P. KASHYAP, Abhinav Vayyeti, Pralambika Roy, Ryan A. Mehl, Richard B. Cooley, Snorri Th. Sigurdsson, Yaakov Levy, Reza Dastvan, , Edwin Antony
This study shows phosphorylation of IGF2BP1 and IGF2BP3 at a conserved serine acts as a configurational switch, altering their RNA binding domain arrangements and affecting mRNA regulation.
bioRxiv · Aug 19, 2026 · PreprintBiochemistry