Mitochondrial one-carbon enzyme MTHFD1L sustains stemness and metastatic progression in breast cancer
Hirokazu KUSUNOKI, Tsunaki Hongu, Tatsunori Nishimura, Kazuki Ogawa, Jin Lee, Yasuto Takeuchi, Koji Okamoto, Tomoyoshi Soga, Noriko Gotoh
This study identifies MTHFD1L as a critical regulator of breast cancer stemness and metastasis, showing its role in metabolic rewiring and tumor progression.
bioRxiv · Jun 19, 2026 · PreprintCancer Biology