Manuel D. Díaz‐Muñoz

A PTBP1-CDC42 splicing axis regulates leukemia growth and venetoclax sensitivity in acute myeloid leukemia

This study identifies PTBP1-CDC42 splicing regulation as a critical factor in AML growth and venetoclax sensitivity, suggesting a therapeutic combination strategy.

Post-transcriptional control of homeostatic B- cell signalling by HuR is required for innate B cell maintenance and function.

This study shows that HuR-mediated post-transcriptional regulation is critical for B-1 cell homeostasis, receptor expression, and function.

Post-transcriptional regulation by TIA1 and TIAL1 controls the transcriptional program enforcing T cell quiescence.

This study identifies TIA1 and TIAL1 as key regulators of T cell quiescence by controlling the expression of transcription factors that restrain homeostatic proliferation.

ORFLine: a bioinformatic pipeline to prioritise small open reading frames identifies candidate secreted small proteins from lymphocytes

ORFLine identifies and characterizes small open reading frames in mouse lymphocytes, revealing novel secreted micropeptides.

Alternative translation initiation generates a functionally distinct isoform of the stress-activated kinase MK2

The paper identifies an alternative translation initiation site in MK2 mRNA that generates a long isoform with distinct functional properties compared to the short isoform.