Christopher J. Phiel

Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes

The paper shows sparse CBX2 nucleates Polycomb proteins to form condensates that regulate facultative heterochromatin and cellular differentiation in mESCs.

Mouse Embryonic Stem Cell Pluripotency Factors Regulate RNA Methylation

The paper investigates how pluripotency factors in mouse ESCs influence RNA methylation, finding that fructose reduces m6A levels and promotes a naive state.

Vitamin C and Transferrin Reduce RNA Methylation in Mouse Embryonic Stem Cells

The paper shows that Vitamin C and transferrin reduce m6A levels and promote pluripotency in mouse ESCs by affecting FTO and m6A regulation.

Regulation of eIF6 through multisite and sequential phosphorylation by GSK3β

This study identifies GSK3β-mediated multisite and sequential phosphorylation of eIF6 as a mechanism to regulate translation and enhance cell survival during serum starvation.

GSK3 Controls Migration of the Neural Crest Lineage

This study identifies GSK3's role in regulating neural crest migration and shows its relevance in neuroblastoma cell migration.