Pilar Esteve

SFRP1 upregulation causes hippocampal synaptic dysfunction and memory impairment

This study shows that SFRP1 overexpression in astrocytes causes synaptic dysfunction and memory impairment in mice, suggesting SFRP1 as a therapeutic target for Alzheimer's disease.

SFRP1 shapes astrocyte to microglia cross-talk in acute and chronic neuroinflammation

This study shows that SFRP1 from astrocytes promotes microglial activation in acute and chronic neuroinflammation, suggesting it as a therapeutic target.

Sfrp1 deficiency makes retinal photoreceptors prone to degeneration

This study shows that Sfrp1 deficiency leads to photoreceptor degeneration and increased light-induced damage in mice, highlighting SFRP1's role in maintaining outer limiting membrane integrity.