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This study evaluates the therapeutic efficacy of SFRP1 neutralization at different disease stages in a mouse model of Alzheimer's disease, finding that early intervention is most effective.

This study shows SFRP1 drives astrocytic glycolytic activation during neuroinflammation, enhancing metabolic flexibility to meet energy demands.

This study shows that SFRP1 overexpression in astrocytes causes synaptic dysfunction and memory impairment in mice, suggesting SFRP1 as a therapeutic target for Alzheimer's disease.

This study investigates how sleep affects cerebellar processing in adult mice by examining correlations between muscle twitches, EEG, and climbing fiber activity during different sleep stages.