Denise Manahan‐Vaughan

Strain- and age-dependent divergence in mouse appetitive spatial learning and decision strategies

This study investigates how mouse strain and age influence spatial learning and decision strategies in a T-maze task, revealing strain- and age-dependent differences in performance and decision policies.

Multiplexed detection of nuclear immediate early gene expression reveals hippocampal neuronal subpopulations that engage in the acquisition and updating of spatial experience

The paper identifies distinct hippocampal neuronal subpopulations in dCA1 and pCA1 involved in spatial representation acquisition and updating using IEG expression analysis.

Sparse memory ensembles set brain-wide network states to sustain learned associations

The paper identifies brain-wide network hubs that support spatial memory acquisition and shows that reactivating memory ensembles during extinction learning prevents its effectiveness.

β-adrenergic receptors modulate CA1 population coding during cumulative spatial memory formation and updating

This study shows that β-adrenergic receptors influence CA1 neuronal population dynamics during spatial memory formation and updating in mice.

Place cell activity and behaviour during task acquisition and extinction learning predict renewal outcome

The paper examines how place cell activity during learning and extinction predicts renewal outcomes in rats, showing that global remapping correlates with successful renewal.

The suprapyramidal and infrapyramidal blades of the dentate gyrus exhibit different GluN subunit content and dissimilar frequency-dependent synaptic plasticity in vivo

This study compares frequency-dependent synaptic plasticity in the suprapyramidal and infrapyramidal blades of the dentate gyrus in rats, finding differences in long-term depression, long-term potentiation, and NMDA receptor expression.

Audiovisual stimuli enhance narrowband gamma activity along the mouse thalamocortical visual circuit

The paper shows that audiovisual stimuli increase narrowband gamma activity in mouse V1, originating from the thalamus, suggesting a new role for the LGN in multisensory integration.

Why do hippocampal mossy cells matter? It depends on the frequency and context.

This study shows mossy cells influence hippocampal function differently based on frequency and context, affecting memory and seizure risk.

Genetic depletion of BDNF impairs both context-dependent and context-independent extinction learning of a spatial appetitive task

This study shows that BDNF depletion impairs extinction learning and renewal in spatial appetitive tasks, both with and without context change.

Context-dependent extinction learning emerging from raw sensory inputs: A reinforcement learning approach

This study develops a reinforcement learning model that learns context-dependent extinction behavior from raw visual inputs, showing that context dependence can emerge without explicit context representation.

Defective synapse maturation and enhanced synaptic plasticity in Shank2-/- mice

This study shows Shank2-/- mice have defective synapse maturation and enhanced synaptic plasticity, providing a mechanistic explanation for increased long-term potentiation.