R. Mark Henkelman

Tmod2 is a regulator of cocaine responses through control of striatal and cortical excitability, and drug-induced plasticity

This study identifies Tmod2 as a regulator of cocaine-induced plasticity and addiction-related behaviors through effects on neuronal excitability and synaptic function.

Why do hippocampal mossy cells matter? It depends on the frequency and context.

This study shows mossy cells influence hippocampal function differently based on frequency and context, affecting memory and seizure risk.

LAMA: Automated image analysis for developmentalphenotyping of mouse embryos

LAMA automates 3D image analysis for mouse embryo phenotyping, integrating with an anatomical atlas to annotate dysmorphologies.

Leveraging biobank-scale rare and common variant analyses to identify ASPHD1 as the main driver of reproductive traits in the 16p11.2 locus

The paper identifies ASPHD1 as a key driver of reproductive traits in the 16p11.2 locus using biobank data, Mendelian randomization, and animal models.

Oscillatory cortical forces promote three dimensional cell intercalations that shape the mandibular arch

The paper shows that oscillatory cortical forces drive 3D cell intercalations in the mouse mandibular arch, shaping embryonic structures through Wnt5a, YAP/TAZ, and PIEZO1.

Cardiac enriched BAF chromatin remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function

This study shows that Baf60c regulates gene expression programs critical for heart development and function by interacting with Myocardin and controlling contractile proteins and metabolic genes.