Epigenetic control of nuclear mechanics and cellular migration via histone H3 lysine 9 methylation at Lamina-Associated Domains
Silvia Comunian, Valentin Petit, Guillaume Velasco, Vlada Zakharova, Cécile Jebane, Pauline Lahure, Véronique Joliot, Laurence Del Maestro, Magali Hennion, Guillaume Lamour, Jean‐Baptiste Manneville, Emmanuèle Helfer, Ekaterina Boyarchuk, Slimane Ait‐Si‐Ali
This study shows that SETDB1 regulates LADs and nuclear mechanics by modulating H3K9me3, affecting cancer cell migration without major transcriptional changes.
bioRxiv · Nov 28, 2025 · PreprintMolecular Biology