Amanda M Brown

Age-Adjusted Cerebellar Volumetry and Developmental Outcomes in Extremely Low Birth Weight Infants

This study examines cerebellar volume in extremely low birth weight infants and finds that age-adjusted volumetric patterns correlate with developmental outcomes.

Cerebellar Purkinje cell stripe patterns reveal a differential vulnerability and resistance to cell loss during normal aging in mice

The paper shows that Purkinje cell loss in aged mice occurs in parasagittal stripes and is linked to motor dysfunction, with similar patterns observed in human postmortem samples.

Cerebellar nuclei cells produce distinct pathogenic spike signatures in mouse models of ataxia, dystonia, and tremor

The paper identifies distinct neural spike signatures in cerebellar nuclei cells across mouse models of ataxia, dystonia, and tremor, showing these signatures can induce specific motor impairments.

Targeting DBS to the centrolateral thalamic nucleus improves movement in a lesion-based model of acquired cerebellar dystonia in mice

This study shows that targeting deep brain stimulation to the centrolateral thalamic nucleus reduces dystonia in a mouse model caused by cerebellar outflow tract lesions.

Purkinje cell dysfunction causes disrupted sleep in ataxic mice

This study shows that Purkinje cell dysfunction in ataxic mice disrupts sleep architecture, with reduced wakefulness and REM sleep and increased NREM sleep.

Influence of data sampling methods on the representation of neural spiking activity in vivo

This study shows that recording duration and approach affect the representation of neural spiking activity, influencing estimates of firing rate and pattern.

Maturation of Purkinje cell firing properties relies on granule cell neurogenesis

This study shows that granule cell neurogenesis is essential for the maturation of Purkinje cell firing properties and cerebellar-dependent behaviors in postnatal mice.

Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules that are defined by distinct pinceau sizes

The paper shows that Purkinje cell neurotransmission organizes basket cell pinceaux into distinct size-based zones.

Maternal cannabis vapor exposure causes long-term alterations in emotional reactivity, social behavior, and behavioral flexibility in offspring.

This study shows that prenatal cannabis vapor exposure in rats leads to long-term behavioral changes in offspring, including altered emotional reactivity, social behavior, and cognitive flexibility.

Cerebellar Purkinje cell microcircuits are essential for tremor

This study shows that Purkinje cell activity is essential for tremor, as silencing it blocks tremor in mice and modulating it with deep brain stimulation reduces tremor.

Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells

The paper investigates how inhibitory molecular layer interneurons influence Purkinje cell firing properties in mice by selectively depleting GABAergic neurotransmission from stellate or basket cells.