Roy V. Sillitoe

This study examines cerebellar volume in extremely low birth weight infants and finds that age-adjusted volumetric patterns correlate with developmental outcomes.

This study identifies a cerebellar-midbrain pathway that selectively gates social vocalizations and demonstrates that targeted neuromodulation can restore vocal behavior without improving motor coordination.

The paper investigates the role of cerebellar inhibitory neurons in dystonic crisis and shows that modulating these neurons can induce or alleviate the condition in mice.

The paper shows that Purkinje cell loss in aged mice occurs in parasagittal stripes and is linked to motor dysfunction, with similar patterns observed in human postmortem samples.

The paper uses stereo-tracking to study Purkinje cell development and identifies a new subcellular structure called axon bubbles.

This study shows cerebellar deep brain stimulation improves both motor and sleep symptoms in dystonic mice.

The paper identifies distinct neural spike signatures in cerebellar nuclei cells across mouse models of ataxia, dystonia, and tremor, showing these signatures can induce specific motor impairments.

This study shows that targeting deep brain stimulation to the centrolateral thalamic nucleus reduces dystonia in a mouse model caused by cerebellar outflow tract lesions.

This study shows that Purkinje cell dysfunction in ataxic mice disrupts sleep architecture, with reduced wakefulness and REM sleep and increased NREM sleep.

This study investigates how cerebellar dysfunction affects sleep in dystonia mice, finding disrupted sleep patterns independent of motor symptoms.

This study shows that recording duration and approach affect the representation of neural spiking activity, influencing estimates of firing rate and pattern.

This study identifies the ventral posteromedial nucleus of the thalamus as a source of tonic-clonic seizures, showing cerebellar input drives seizure initiation.

This study shows that granule cell neurogenesis is essential for the maturation of Purkinje cell firing properties and cerebellar-dependent behaviors in postnatal mice.

This study shows that deleting Mecp2 from the entire cerebellum, but not from individual cell types, causes a delay in motor learning in mice.

The paper shows that Purkinje cell neurotransmission organizes basket cell pinceaux into distinct size-based zones.

This study shows that cerebellar stimulation impairs spatial working memory and disrupts mPFC-dCA1 coherence, suggesting a role for the cerebellum in modulating prefrontal-hippocampal interactions during decision-making.

This study shows that Purkinje cell activity is essential for tremor, as silencing it blocks tremor in mice and modulating it with deep brain stimulation reduces tremor.

The paper investigates how inhibitory molecular layer interneurons influence Purkinje cell firing properties in mice by selectively depleting GABAergic neurotransmission from stellate or basket cells.

The paper shows that cerebellar Purkinje cells in awake mice encode phase differences between oscillations in the medial prefrontal cortex and hippocampus during spatial working memory tasks.