Hassan Fazilaty

This study identifies Wnt7b as a critical autocrine WNT ligand required for survival of BRAF-mutant colorectal cancer organoids and shows its association with poor patient survival in human tumors.

This study identifies APOA1 as a marker of a late fetal colonic epithelial state that reappears after injury, linking it to colonic maturation and injury responses through interactions with WNT5A and regulation by HOXB7.

The paper integrates single-cell data from CRC patients to identify immune subtypes and neutrophil phenotypes, revealing their spatial organization and tumor-induced changes.

RoCK and ROI improves single-cell transcriptomics by targeting specific transcripts and regions, enhancing detection of critical biological features.

This study shows eosinophils inhibit CRC metastasis by blocking SPP1+ macrophage differentiation, using transcriptomics and a murine model.

This study introduces oncoembryology to identify SoxC transcription factors as regulators of colon development and cancer, showing their role in tumor growth and metastasis.