A Phosphorylation-Induced Micellization switch in the low complexity domain of TDP-43
Rodrigo F. Dillenburg, Lopatina Anastasia, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Hesselbarth, Frank Schafer-Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas S. Stelzl, , Edward A. Lemke
This study shows phosphorylation of TDP-43's low-complexity domain shifts its self-assembly from macrophase separation to micellization, potentially protecting against pathological aggregation.
Advanced Science · Jul 28, 2026Peer-reviewedBiophysics