Samuel J. Taylor

Transitory enhancement of GATA2 chromatin engagement during early erythroid differentiation

The paper uses live-cell imaging and CUT&Tag to show that GATA2 chromatin binding kinetics change during early erythroid differentiation, with a transient increase in long-lived binding.

ATG-18 drives longevity in an HLH-30-dependent manner

This study shows that ATG-18 overexpression extends C. elegans lifespan and improves stress resilience through the HLH-30 transcription factor, while also revealing a temporal-specific effect on heat stress survival.

NMNAT1 Binding at Promoters and Enhancers Couples NAD+ Synthesis to RNA Polymerase II Engagement

This study identifies NMNAT1's role in transcriptional regulation by showing its binding to gene promoters and enhancers and its impact on RNA Polymerase II occupancy.