Matthew J. Gamble

The paper shows PRMT5 promotes chromatin escape of mRNAs by methylating SNRPB, affecting splicing and nuclear export.

This study identifies NMNAT1's role in transcriptional regulation by showing its binding to gene promoters and enhancers and its impact on RNA Polymerase II occupancy.

The paper identifies H2BK120ac as critical for BRD4 recruitment to intergenic enhancers and shows its role in BRD4-NUT-driven oncogenesis.

This study shows that platelet PI3Kβ promotes breast cancer metastasis by enhancing tumor cell invasion and signaling pathways, suggesting it as a therapeutic target.

This study measures Pol II elongation and splicing kinetics genome-wide and finds they are coordinated by spatial genomic organization, particularly within TADs.