ATG-18 drives longevity in an HLH-30-dependent manner
Tomas Schmauck‐Medina, Alexander S. Anisimov, David H. Meyer, Yue Hu, Zebo Huang, Yue Wu, Samuel J. Taylor, Michael Takla, Michael Robert MacArthur, Sarah Jayne Mitchell, Ruixue Ai, Anne Simonsen, Vidar Jensen, John P. Labbadia, HAN-MING SHEN, , Evandro Fei Fang
This study shows that ATG-18 overexpression extends C. elegans lifespan and improves stress resilience through the HLH-30 transcription factor, while also revealing a temporal-specific effect on heat stress survival.
bioRxiv · Jan 29, 2026 · PreprintMolecular Biology