Po‐Han Chen

PepRePs: Peptide-Retargeted Phosphatases Designed with Generative Language Models

This paper introduces PepRePs, a system using peptide-retargeted phosphatases to selectively manipulate protein phosphorylation, showing reduced phosphorylation and downstream effects on cellular processes.

Nanobody MET CAR T cells show efficacy in solid tumors

This study demonstrates that MET-targeting VHH-CAR-T cells effectively kill tumor cells in vitro and control tumor growth in vivo.

Unilateral optogenetic inhibition and excitation of basal ganglia output show opposing effects on directional lick choices and movement initiation in mice

This study uses optogenetics to show that unilateral inhibition and excitation of basal ganglia output to motor thalamus in mice oppositely affect directional licking choices and movement initiation.