Author

Mohammed Alhusayan

University of PennsylvaniaORCID 0000-0002-9488-0752Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Aqsa Yashfeen· 1 shared Arul M. ChinnaiyaniD· 1 shared Benjamin Garcia· 1 shared David M. FeldseriD· 1 shared Erick Mitchell-VelasqueziD· 1 shared Hyein Cho· 1 shared Irfan Ahmed AsanganiiD· 1 shared Javed Siddique· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Aqsa Yashfeen

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1 paper

Recent·Most cited

NNMT Loss Drives Cancer Progression by enhancing SAM availability for mTORC1 Signaling and Chromatin Methylation

Qu Deng, Erick Mitchell-Velasquez, Sharan Venkatesh, Rahul Mannan, Hyein Cho, Mohammed Alhusayan, Aqsa Yashfeen, Ramakrishnan Natesan, Natarajan V. Bhanu, Radha Paturu, Javed Siddique, Rohit Mehra, Sooryanarayana Varambally, Benjamin Garcia, David M. Feldser, , Irfan Ahmed Asangani

This study identifies NNMT as a tumor suppressor in prostate cancer that regulates SAM availability, mTORC1 signaling, and chromatin methylation, revealing a therapeutic strategy using dietary methionine restriction and mTORC1 inhibition.

bioRxiv · Jul 1, 2026 · PreprintCancer Biology